/ip firewall address-list
add list=no_HTTP address=192.168.0.200
add list=no_HTTP address=192.168.0.201
/ip firewall filter
add chain=forward src-address-list=no_HTTP protocol=tcp dst-port=80 action=drop
Blocking web sites via URL: http://wiki.mikrotik.com/wiki/How_to_Block_Websites_%26_Stop_Downloading_Using_Proxy