I have the exact same problem as Ehman.
Using a K4201-z Dongle when I plug it into the USB port no PPP-client is automatically generated and when I manually generate one and attempt to connect to USB1 and then view the info on the dongle I am presented with the error "Couldn't start, unable to acquire port (6)"
I am using the latest version of both firmware and software (6.10) when the K4201-z is supposedly compatible with 6.8. When walking through pliskens link
here I can get through to the section about when plugging in the device and the LTE interface appearing. Everything prior to this stage is either set-up automatically in the same was as described or works (i.e. can view the dongle in System > Resources > USB and is represented as shown in the link.
So I am out of luck, have tried contacting the retailer and they were no help so it is either find help here or contact Mikrotik with the support file and see what they can do to fix the problem. So any further ideas about how to get the K4201-z and RB750UP to work together?