The timeouts can occur if DUDE server VS routers rOS is to far apart (if it caught one of the big updates like 6.46.3 to 6.46.4 breaks it)
Can also be permissions or IP>Services allowed IP's (of course winbox port follows that too)
We had this issue if the storage device for database was garbage. Moving to SSD fixed our issue with this2020 and still he we are with the same problem.
Oh, i didnt realize that is what you ment. That is how we are setup as wellThere is additional custom user group with passive rights and dude connects by user which is member of that group. Dude is not connecting with admin rights to the devices.