Yes and no.
The usual advice, and also Rule #6:
The twelve Rules of Mikrotik Club
is to have the bridge set as auto-mac=no and explicitly assign a static IP as admin-mac, but it is not carved in stone.
You can prepare your "base" configuration with auto-mac=yes, and then - while you make the needed small individual changes on the router configuration - set it statically (the usual MAC used is the one of the first interface in the bridge, usually ether2).
See also:
The possible issue (not really common in practice) with auto-mac=yes is that - should the order of the ports inside the bridge change - the bridge MAC may also change, creating havoc in certain setups, but while setting up the devices it should not be a problem.