Both are fine, first is slightly preferable since you don’t need to involve conntrack. In general though you should block everything on the filter input chain and only open things you need.
This is the right way:
/ip firewall raw
add action=drop chain=prerouting dst-port=53 in-interface=ether1 protocol=tcp
add action=drop chain=prerouting dst-port=53 in-interface=ether1 protocol=udp