Does it matter ...

Does it matter what network the Local IP address is assigned from?
I’m running 4 networks (vlans) on this router.

/ip address
add address=192.168.10.10/24 interface=10vlan network=192.168.10.0
add address=192.168.200.1/24 interface=200vlan network=192.168.200.0
add address=192.168.150.1/24 interface=150vlan network=192.168.150.0
add address=192.168.250.1/24 interface=250vlan network=192.168.250.0

The vlans all have the same access to the internet, but not each other and the separation is primarily for the different locations of the end users in three separate buildings.
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You should only ever use Quickset once (for a basic single LAN to WAN setup), or never (and perform all of the configuration manually).

After you make changes through Winbox / Webfig, especially to networks, VLANs, firewall rules, etc., running Quickset again will cause undefined changes.