Getting Packet Loss Using Ping Tool

Dear Members

I have created GRE over IPSEC between two networks and successfully getting LAN to LAN ICMP response. This configuration is running smoothly dince last 6 Months. Today all of a sudden when I tried to take LAN to LAN ICMP response using ping tool on mikrotik router I am getting heavy packet loss but upon doing ICMP from connected host on both ends response is fine without any packet loss.I am using RB750GR3 at one end and RB750GR2 on other end.

Can somebody help to understand and resve this?

Muhammad