Support for e-sim is in the works, but it will only work on the new hardware with an added dedicated chip, see:
http://forum.mikrotik.com/t/esim-in-7-18rc/182138/1
So, maybe there will be a hap Ax lite LTEx refresh (or mark II or e-sim edition or whatever name the marketing department of Mikrotik will come out with in order to better confuse customers) with the needed hardware or maybe not.
For existing devices there are possible workarounds, like esim.me or 5ber:
https://esim.me/
http://esim.5ber.com
but you need an android device and the app to manage the actual esims, and the compatibility with Mikrotik (or Quectel) devices is not guaranteed.
There is also this one, that allows managing on windows/Linux through a reader:
https://www.estk.me/
but it is at the moment focused seemingly on Asia only.