Helldivers 2 connection issues with Mikrotik configuration?

Not a MT issue, its something with the game itself. I suspect the anti cheat does not know how to handle it properly. My game will be working fine with IPV6 disabled. As soon as I enable it again then the game cannot connect to other players. I have to disable IPV6, change my IPV4 to a different address and re install the game. only then it starts to work again.