I connect all my computers 192.168.1.1/24 with port1. I wonder if I want to block computer A 192.168.1.10/24 to communicate with computer B 192.168.1.11/24 it’s possible to do that?
Do you mean that ether1 is connected to a separate switch where all your computers are connected to?
If that is the case, what you want is impossible since the communication between the computers does not travel over the RouterBoard. This traffic is handled by the switch
But I’m using with a normal switch connected to ether1 (192.168.1.1/24) and all my computer connected to that switch , and i wonder if the Mikrotik can block all the communication from Computer A 192.168.1.10/24 to Computer B 192.168.1.11/24.
No - with a standard switch the traffic between hosts at 192.168.1.10 and 192.168.1.11 will (assuming both hosts have netmasks 255.255.255.0) travel via the switch and the RouterBoard will not be involved in the path therefore will have no control over the traffic.