Some Port 80 traffic not passing through

Using Router OS 2.9.27
I’m not positive this is a Mikrotik issue but it seems to be the bottleneck.

I work for a small Wireless ISP. We have towers in several locations (all in bridge mode) all joined together by a 9-port Mikrotik box. Our client radios are all accessible via a web interface on port 80 and run in bridge mode. We’ve got one customer running a basic web server from his house, also setup on port 80. Our entire wireless network is running on private IPs. We have a Cisco router joining the Mikrotik to the internet.

The Mikrotik box is running in router mode. To summarize the current configuration:
Ethernet 1 (10.5.1.4/24) - backhaul to our Cisco router, and the T-3
Ethernet 2 (10.2.6.1/24) - link to 1 access point (has the web server on it as well)
Ethernet 3 (10.5.2.1/24) - link to another access point

Each of the ethernet ports is using it’s own /24 subnet of private ips, the default gateway of the Mikrotik box is 10.5.1.1.

I am able to ping the server and access all other open ports (DNS, Mail, Terminal Services, etc) on it from any interface, including the public IP NAT’d (probably not abbreviated right) through the Cisco. From the Cisco side (ethernet 1) I can access the web interfaces of the client radios but not the server. From the access point on Ethernet 3 I can access the server with no problems, as well as all the client radios. From the access point on Ethernet 2 I can access all of the radios and the server. All of the clients are able to access the internet. I also tried bypassing the Cisco box and hooked my workstation directly up to the backhaul link going to the Mikrotik box to make sure the Cisco wasn’t the issue.

The server in question has been up and running the same setup for over a year now and started having problems just in the last couple of weeks.

I would appreciate any assistance that can be provided. If something is not clear let me know.