When you say “access”, do you mean with just ping, or other services (HTTP, UNC, etc.)?
If just ping… check any firewall filters on the RB.
If other services, your issue may be NAT. With NAT enabled, when your devices reply back, they get src-nat-ed to the router IP, which the other end in turn treats as an invalid connection (since it was expecting the actual IP). You need to tweak the NAT rule so that it does masquerade/src-nat only if the dst-address is not in the 192.168.6.0/24 subnet.
What does not work? 192.168.1.x hosts not being able to reach Internet? Or pings from VDSL to LAN ips?
I’d check the VDSL modem NAT to make sure it masquerades both .1.0 and .6.0 networks (or 192.168.0.0/16) and disable nat on the mikrotik if you want to be able to ping from other .6.0/24 hosts (guess there are more apart from the VDSL itself?)
I suspect that your traffic between 192.168.1.0/24 and 192.168.6.0/24 is being blocked by rule #3. If you want bilateral communication, you need to create a filter rule that explicitly ALLOWS communication between those two subnets.
The easiest thing to do would be to create an address list with both subnets. Then, create a filter rule above your drop rule (currently #3), specifying the address list you created in both the src and dest address lists. Change action to accept and in-interface to ether1.
Alternatively, you could disable all the firewall rules altogether if you don’t need any additional protection - such as if your VDSL router is already firewalling internet traffic for you and you don’t want to hinder any type of communication between 192.168.6.0/24 and 192.168.1.0/24. This would essentially put your RB750 in router-only mode.
Lastly, make sure that any client devices on either LAN have firewall rules to allow traffic to 192.168.6.0/24 or 192.168.1.0/24. Sometimes the built-in firewall (especially on Windows machines) will block traffic outside its local subnet.