Winbox and Dude connection refused

RB1100AHx4DE produced an error message when Winbox, Dude and TikAPP tried to connect, “connection refused”.
SSH ok and www webfig ok. No errors or events in the log except SSH and Webfig connections.
Firmware version 6.42.12 Stable with 35days uptime. Memory usage a bit high with 486MB free of 1024MB.
In Webfig I disabled the /ip/Winbox service then re-enabled it clearing the issue.
Has anyone encountered this issue?

Looks like some general similarities in this post -
http://forum.mikrotik.com/t/dude-constantly-freezing/134176/1
Disabled and re-enabled Winbox port.