Wireguard VPN Mikrotik

Hi guys, I recently configured wireguard on my mikrotik, and I was able to filter which IP addresses used the VPN, I am happy with that because I only activated it for the home TVs using static IP, the other devices do not use VPN, my question is is there a way that the VPN only works for one website? For example

Netflix.com, and the other apps that do not use VPN on my TV

The question is not clear and your wireguard even less so. Are you using a third party VPN server or do you have a public IP and are hosting your own WG client server (for handshake) on the router.

Sorry, I’m using a third-party VPN, Wireguard is configured with a third-party VPN, and it works perfectly, for example my TV has the IP 192.168.88.2 and has access to the VPN, but I would like to be able to make only one app have access, for example Netflix and that YouTube does not use VPN

Sorry, MT is not an app based appliance.
THe best thing you can do is
a. make a wifi subnet/vlan on the router that will only go to wireguard, and in this way anyone wanting to use third party for internet, can use that SSID, assuming you have given them the WLAN password.
b. if this is for wired networks then suggesting that you create a vlan/subnet just for traffic going out wireguard. If this is at an entertainment station, simply put a managed switch at that location and have all vlans feeding the switch for example incoming on port1, normal internet on port2 wireguard on port 5 etc… Just plug in which source required.

Ok, so it is not possible to filter a specific web page for the use of the correct VPN?

Nope… not to my knowledge.