Might be an MTU issue. Does MSN messenger work?
It could be that the site where Outlook Web Access (OWA) is not working has an ADSL connection or something else along the path, which needs to fragment. I'm not sure about OWA, but MSN Messenger and Hotmail don't like it when the client needs to perform path MTU discovery.
The solution to that is to add two IP --> Firewall --> Mangle rules. Something like this:
NB: Replace [INTERNET INTERFACE] with your internet-facing interface
/ip firewall mangle
add chain=forward action=change-mss new-mss=1420 tcp-flags=syn protocol=tcp in-interface=[INTERNET INTERFACE] tcp-mss=1421-65535
add chain=forward action=change-mss new-mss=1420 tcp-flags=syn protocol=tcp out-interface=[INTERNET INTERFACE] tcp-mss=1421-65535