Didn't realize you were using multiple NICs, would have suggested the same as here: viewtopic.php?p=595412#p595412
I'm not sure if its windows or winbox, could be a tossup. The other day wireshark wouldn't detect wired (usb) or wireless NICs on a win10 laptop of mine, re-boot solved it, who knows.
I frequently disable/enable NICs for various reasons so it sometimes doesn't occur to me that some might not consider that a part of a trouble shooting process.
I may not be hitting the command line in windows every day to add routes, but it's something that is sometimes required and involves essentially the same trouble-shooting process. Example: you have a routing problem on a windows machine, maybe windows is trying to route through the wrong NIC, disable NIC temporarily or fix route, move on.
When you are having difficulty connecting 2 devices, rule out the machine you are using by trying another. I would not assume multiple devices are faulty without trying another machine or completing a "without a doubt" level of trouble-shooting.
It's a little unclear what the default configuration had to do with this, but i've never used these devices specifically.