Location 1 : Mikrotik VPN Configured.
Location 2 : PC

from location 2 i can access location 1 all pc and use server as local by connect VPN. From yesterday Location 2 ISP Block VPN Access. i cant connect VPN with id password of Location 1.

Now how can i bypass this block. any port change or other system. please help. i'm facing really big problem for this.

You can try to use SSTP VPN or other VPN, actually which VPN is configured?