So basically a standard modem setup.
update to latest firmware and then use winbox to setup.
First except the default setup to get it up and running with one pc and and an internet connection.
Then apply some security rules (such as creating a new user with password and deleting the admin user.).
Do everything in safe mode (near top of winbox menu once logged into the unit) and if you do something illegal and the router kicks you off you will be able to log back in to a state you were before invoking safe mode. So typically do a couple of steps. all good flash safe mode off and then back on and continue.
https://wiki.mikrotik.com/wiki/Manual:S ... our_Router
once you get to this stage, then state what requirements you have that are particular to your setup..