I would start by putting the passthrough=no rules immediately following the rules which create the connections marks they look for. I think you will spend less time comparing traffic for each possible condition before short circuiting out of the loop.
Then, look for the set of rules which see the most traffic in the bytes or packets counters. Make sure the highest traffic conditions are matched earliest in the rule order. That will permit the passthrough=no rules for the highest volume condition to short circuit evaluation of all following rules as quickly as possible saving the most possible CPU time.