QuickSet is a "wizard" to do a quick setup for you, it has a limited set of tweakable parameters, as otherwise you could (if you knew how) set it up through winbox as you please.
what do you want to set up? a PPPoE client on ether2??
FWIW, ether1 is usually the port devoted to WAN because is commonly connected directly to the router's CPU.
A tip: use Quick setup and configure until you have a working router.
Once you achieve this, open a new terminal, and issue
That file will contain all the CLI commands needed to setup a blank router to that same configuration. So you could edit it changing the parameters you wish, reset your router blank (no defaults) then paste all those commands in a terminal and get that new setup loaded.
To download, go to winbox, File, and drag MySetup.rsc to your PC (or download it through FTP from the router).
What are you trying to achieve?