I use the Safe Mode feature all the time. There should be a reverse version where the settings made in winbox don't get applied until you disable that mode
It would be awesome if there was a feature that allowed you to enable like "batch" mode, but instead of applying all the settings immediately, it would wait until you turn off "batch" mode, then winbox sends all those commands in sequence to apply the changes.
Currently I use scripts to schedule change-sets. Sometimes I just need to do a one off config of a device so having this feature in winbox could save a lot of time trying to reconnect after breaking changes.