Sorry, I guess the main question was - will IPSec/IKEv2 work fine on mikrotik device which has multi WAN connections.
Additionally, my ISPs provide different benefits, so I route youtube/netflix to one of them, the rest of the traffic is splitted between two (2/1). Will I be able to spin up two IPSec/IKEv2 connections and follow the described above logic?
For the reference my mangle rules look as follows:
/ip firewall mangle
add action=mark-connection chain=input connection-mark=no-mark in-interface=plus new-connection-mark=plus_conn passthrough=no
add action=mark-connection chain=input connection-mark=no-mark in-interface=orange new-connection-mark=orange_conn passthrough=no
add action=mark-routing chain=output connection-mark=orange_conn new-routing-mark=to_orange
add action=mark-routing chain=output connection-mark=plus_conn new-routing-mark=to_plus
add action=mark-connection chain=prerouting comment="Plus PCC 3/0" connection-mark=no-mark dst-address-list=!LAN dst-address-type=!local in-interface-list=LAN new-connection-mark=plus_conn passthrough=yes \
per-connection-classifier=both-addresses-and-ports:3/0
add action=mark-connection chain=prerouting comment="Plus PCC 3/1" connection-mark=no-mark dst-address-list=!LAN dst-address-type=!local in-interface-list=LAN new-connection-mark=plus_conn passthrough=yes \
per-connection-classifier=both-addresses-and-ports:3/1
add action=mark-connection chain=prerouting comment="Orange PCC 3/2" connection-mark=no-mark dst-address-list=!LAN dst-address-type=!local in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes \
per-connection-classifier=both-addresses-and-ports:3/2
add action=mark-connection chain=prerouting comment=youtube dst-address-list=youtube in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=youtube.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.youtube.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=googlevideo.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.googlevideo.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=youtu.be
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.youtu.be
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=ytimg.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.ytimg.com
add action=mark-connection chain=prerouting comment=Netflix dst-address-list=netflix in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=netflix.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.netflix.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.nflxext.com
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.nflxvideo.net
add action=mark-connection chain=prerouting dst-port=443 in-interface-list=LAN new-connection-mark=orange_conn passthrough=yes protocol=tcp tls-host=*.nflxso.net
add action=mark-connection chain=prerouting comment="NordVPN Poland #136" disabled=yes dst-address-list=pl136_vpn dst-address-type=!local new-connection-mark=orange_conn passthrough=yes
add action=mark-routing chain=prerouting comment="Plus Routing Mark" connection-mark=plus_conn in-interface-list=LAN new-routing-mark=to_plus passthrough=no
add action=mark-routing chain=prerouting comment="Orange Routing Mark" connection-mark=orange_conn in-interface-list=LAN new-routing-mark=to_orange passthrough=no