In firewall rules there are options in-interface and out-interface allowing user to specify which interface rule applies to. It also allows negation on specified interface which means rule applies to all interface but one specified.
Problem arises when there are several interfaces on board but rule has to apply to selection of them (two or more). For example, there may be several wan and several lan interfaces and there is need to handle only all lan or only all wan interfaces (or anything but lan interfaces, or anything but wan interfaces).
There is no option to handle such situation with single rule, so user must create several rules to handle this. It is ok when there is one or two rules, but if there is whole system of rules that should be applied things become messy.
I would suggest for Mikrotik developers to allow setting list of interfaces for in-interface and out-interface.