We been trying to sen a email in routeros 5.19 and is not working, when we send from a 4.11 os version it´s ok, sents the email ok

Works fine for me. You did notice that parameters changed a bit between 4.11 and 5.19 right?

This is what we are doing:
/tool
/e-mail
send to="user@domain.com" from="<user1>" body="test0" subject="test0" server="x.x.x.x" password="xxxxx" user="me@mydomain.com" port="25"
and in 4.11 works fine, not with the same parameters
but in 5.19 we get error connecting to server
if we ping the server, it pings ok, its in the same subnet

Thank´s

I have had my fair share of e-mail problems, but it always comes down to misconfiguration (firewall in either end, spamfilter frontend and so on), never RouterOS. And as mentioned already, I have 5.19 sending mails like a charm.

If you want to check what is happening, then enable verbose email logging. Try another email send, then check the log.

Nothing just:
Error sending E-mail <subject>: error connecting to server

but we can ping the server, even telnet the email server
Thank´s

maybe server requires authentication, or uses another port ?

We tried also with gmail
tls activated, port 587
and we get the same error
We are doing this in a 450g
and in a 411 with 4.11 that is in the same subnet we can get it working
Thank´s

/tool e-mail
set address=173.194.77.108 from=mikrotik@mydomain.net password=emailpwd port=587 starttls=yes user=user@gmail.com

/tool e-mail send to="user@gmail.com" body="Router email" subject="$[/system identity get name] $[/system clock get time] $[/system clock get date] Alert" from="mikrotik@mydomain.net" server="$[:resolve "smtp.gmail.com"]" tls=yes

This works for me (you need to update the email addresses and password, of course)

Solved!
different port
Thanks to anyone

I'm having other e-mail issues with 6.7

I'm sending email with this:
/tool e-mail> send from=mail@mail.com to=mail2@mail2-com server=x.x.x.x port=25 user=someuser password=somepwd subject="Message subject"
body="Message"

and the command does not send subject or the body (check the attachment). Any ideas?