simply specify the actual value as parameters for change,
first example:
/ip route set parameters=value [find where comment="actual comment" and distance=1 and dst-address=1.11.23.0/24 and gateway=89.22.121.4 and pref-src=89.22.121.2]
inside [ ] you can omit or place any parameters, but do not place less than identifyng correctly the route.
second example:
identify each static route with one comment, like "RT0000023" or "RT0000023 never mind about other comment here" (for unique comment ID use only letters and numbers, and use "0" as placeholders)
and do tis:
/ip route set parameters=value [find where comment~"RT0000023"]