"application" disables all Windows scaling settings and only use the app developer's setting (winbox will appear in its original size) or ones with altered DPIs by other means (which of course will give weird appearance).Like shown in the my examples, the problem exists.Like shown in the examples, there is no problem with any monitor settings. If you have a problem, maybe it is caused by something else in your PC.
Choose the right settings. "System (Enhanced)" and in system->display->advanced scaling settings "Let windows try to fix apps so they're not blurry"
150% scaling and nothing in winbox is blurry