Hi.
I have a mikrotik router 192.168.88.1 and another webserver with following ip : 192.168.88.21, also I have a static real ip address.
I was able to configure remote management of mikrotik via internet.
Now I wnat to make forwatding to webserver, like, x.x.x.x:10000 and it will forward to 192.168.88.21 80 port.

I have created a firewall rule, did everything by manual. Please see the attachments.
The web server is responding locally.
Please advice.

My advice:

Reset your device and start configuring from scratch up. Your firewall is a joke (being polite), and you only want to do remote management through VPN.
You might even want to consider a netinstall as your device could very well be compromised.

Please read:
https://help.mikrotik.com/docs/display/ROS/Netinstall
https://help.mikrotik.com/docs/display/ ... t+Firewall

Once you have your new setup ready to go, the default firewall rules are your friend to start off with!
then export your config and we can go from there.....

/export file=anynameyouwish

(which router by the way?)