Hello.
I upgraded from two RB750s to one RB1100.
I installed latest stable 4.16 but I have problems with freezes.
So I installed 5RC5, all is now functional. I have 13 public IP addresses,
so they are assigned to one port connected to ISP gateway (concretely port 13).
Network is x.x.x.48/28 and x.x.x.49 is external gateway
and x.x.x.50 - x.x.x.62 are addresses I defined in Mikrotik.
I added addresses one by one. With about 4 addresses I do some restarts
and all was OK. When I set up all 13 addreses all was functional
until first restart. After reboot, gateway x.x.x.49
is reachable only about 5 or 10 seconds.
Then pings to x.x.x.49 from Mikrotik does timeout and I can’t access Internet.
When I disabled all or some of public IP addresses and then
do slow enabling of all addresses, router is again functional.
But I must do it after each restart! 
Thank you for help.
could you post full ‘/ip address print’ list of the router?
on my test router i executed this script:
:for i from=1 to=254 do={ip add add address="172.16.15.$i/24" interface=lo }
and rebooted router without problems.
And gateway is reachable? Here is my ip address configuration.
/ip address
add address=xx.xx.xx.51/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=192.168.8.1/24 broadcast=192.168.8.255 interface=ether8 network=192.168.8.0
add address=192.168.3.1/24 broadcast=192.168.3.255 interface=ether3 network=192.168.3.0
add address=192.168.7.1/24 broadcast=192.168.7.255 interface=ether7 network=192.168.7.0
add address=xx.xx.xx.52/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.53/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.55/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.57/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.58/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.59/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=192.168.1.1/24 broadcast=192.168.1.255 interface=ether1 network=192.168.1.0
add address=192.168.5.1/24 broadcast=192.168.5.255 interface=ether5 network=192.168.5.0
add address=192.168.2.1/24 broadcast=192.168.2.255 interface=ether2 network=192.168.2.0
add address=192.168.9.1/24 broadcast=192.168.9.255 interface=ether9 network=192.168.9.0
add address=xx.xx.xx.50/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.56/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.54/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.60/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.61/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=xx.xx.xx.62/28 broadcast=xx.xx.xx.63 interface=ether13 network=xx.xx.xx.48
add address=192.168.88.1/24 broadcast=192.168.88.255 interface=ether1 network=192.168.88.0
add address=192.168.10.1/24 broadcast=192.168.10.255 interface=ether10 network=192.168.10.0