There are two Wireguard@RouterOS guides around that I know of, pretty basic simple one:
http://forum.mikrotik.com/t/mikrotik-wireguard-server-with-road-warrior-clients/148392/1
And an overly complicated and hard to read one:
https://forum.mikrotik.com/viewtopic.php?t=182340
But still worth reading both of them to get a grasp of the config.
If you encounter any weird issues feel free to open a topic about it.