3 windows:
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interfaces window open (device has 5 ports)
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window with Traffic for interface ether 1 open
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window with Traffic for interface ether 2 open
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at peak - 3,3GB of memory used - after ~10 minutes of running, Winbox becomes unresponsive
Update 
memory leak and crash happens when 3D acceleration for VBoxSVGA driver is enabled. After disabling it problem did not occur.
