Sadly, I want to set it up for mobile clients, so this is not really helpful.
I tried a lot and stumbled upon these threads:
http://forum.mikrotik.com/t/mikrotik-wireguard-server-with-road-warrior-clients/148392/1
http://forum.mikrotik.com/t/wireguard-in-roadwarrior-mode-routerosv7/147716/1
and I am having the same issues. I can establish the wireguard connection but no forwarding to internal networks happens. I don’t see any dropped packets in the firewall either, also I moved all relevant allow rules to the top of the firewall.
Would be nice if there is an example of how to configure this and maybe also a troubleshoot section.
On my tests I also noticed various issues regarding wireguard interface/peer changes kind of freezes the router: http://forum.mikrotik.com/t/7-1b6-changes-to-wireguard-interfaces-peers-sometimes-freezes-partly-the-router/150752/1
which makes testing way more complicated.